NAD+ & NMN: The Complete Longevity Stack
Longevity Science
NAD+ and NMN:
What Is in Each Formula, and What the Research Shows
Two of the most actively studied compounds in ageing biology. Here is exactly what we put in each bottle.
How NAD+ and NMN Work
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. Your cells use it in hundreds of enzymatic reactions, including energy metabolism, DNA repair and cellular signalling.
Verdin, reviewing the field in Science (2015), describes NAD+ as central to mitochondrial function and to the sirtuin enzymes, and sets out how NAD+ availability changes over the course of normal ageing.
Why Both NAD+ and NMN
Most longevity supplements give you one or the other. NAD+ and NMN enter the same system at different points:
Vital NAD+
The coenzyme itself. 500mg of NAD+ per serving, formulated alongside quercetin and resveratrol standardised to 98%. Thirty servings per bottle.
Vital NMN
The precursor. 500mg of Beta-Nicotinamide Mononucleotide per serving — the compound your body converts into NAD+ through its own biosynthesis pathway. Thirty servings per bottle.
Together: the coenzyme and the precursor your body builds it from, in one stack, at the amounts printed on both panels.
The Longevity Stack
1x Vital NAD+ (30-day supply) + 1x Vital NMN (30-day supply)
Bought as the stack, the pair costs less than the two bottles bought separately — and the launch discount applies on top.
Compare Your Options
| Vital NAD+ | Vital NMN | Longevity Stack | |
|---|---|---|---|
| Mechanism | The coenzyme itself | NAD+ precursor | Both pathways |
| What is in it | 500mg NAD+, with quercetin and 98% resveratrol | 500mg NMN | Both formulas, full amounts |
| Supply | 30 days | 30 days | 30 days (both) |
Want CoQ10 as well? The Longevity & Cellular Stack adds 200mg of CoQ10 to these same two formulas.
What the Research Shows
NAD+ and NMN are among the most actively studied compounds in longevity and ageing research:
- Energy metabolism: NAD+ is essential for mitochondrial function and ATP production — the primary energy currency of cells. (Verdin, Science, 2015;350:1208–1213)
- Sirtuin activation: NAD+ is a required co-substrate for sirtuins (SIRT1–7), proteins involved in DNA repair and metabolic regulation. (Imai & Guarente, Trends in Cell Biology, 2014;24(8):464–471)
- NMN in humans: A randomised, placebo-controlled trial found that NMN supplementation raised muscle insulin sensitivity. The full finding is set out below. (Yoshino et al., Science, 2021)
The NMN human trial, in full
Yoshino and colleagues ran the first randomised, placebo-controlled trial of NMN in humans: 250mg daily for ten weeks in 25 postmenopausal women with prediabetes and obesity. Insulin-stimulated glucose disposal, measured by hyperinsulinemic-euglycemic clamp, rose about 25% on NMN and did not change on placebo. Muscle insulin signalling (phosphorylation of AKT and mTOR) increased on NMN as well.
That trial used 250mg; our capsule is 500mg. Yoshino J, Baur JA, Imai S-i, et al. “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.” Science, 2021;372(6547):1224–1229. DOI 10.1126/science.abe9985. PMID 33888596.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.