The molecule that lets everything else do its work.
NAD+ is not a vitamin and not a stimulant. It is a helper molecule, and its job is to make other things possible: almost every reaction that turns the food you eat into usable energy needs it present, and so do the enzymes that repair damaged DNA. Your cells use it up and rebuild it constantly, in every tissue you have, all day long.
- ✓ The helper molecule almost every energy reaction needs present
- ✓ Also required by the enzymes that repair damaged DNA
- ✓ 500mg per serving, with quercetin and 98% resveratrol alongside
- ✓ 60 capsules — a 30-day supply
Two capsules daily. Pair it with Vital NMN as the Longevity Stack.
Vital NAD+
$52.90
What is in it, and what the research shows
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell. It is central to how cells turn food into usable energy, and it is the required co-substrate for the sirtuins and for the PARP enzymes involved in DNA repair. That is settled biochemistry, and it is why this pathway gets the attention it does.
Each serving delivers 500mg of NAD+ alongside 250mg of quercetin and 150mg of Japanese knotweed extract standardised to 98% resveratrol. Quercetin is a plant flavonoid and resveratrol a polyphenol found in grapes and berries; both are the subject of ongoing research into cellular metabolism.
The published human trials in this field were run on NAD+ precursors rather than on NAD+ itself, and it is worth knowing what they measured. Yoshino and colleagues (Science, 2021) gave 250mg of NMN daily for ten weeks to twenty-five postmenopausal women with prediabetes and measured a roughly 25% improvement in muscle insulin sensitivity. Elhassan and colleagues (Cell Reports, 2019) gave older men 1g of nicotinamide riboside daily for three weeks, raised NAD+ metabolites in muscle, and lowered several inflammatory markers. Those are results for those precursors at those doses. If you want the form given in the NMN trial, that is Vital NMN.
Read our full NAD+ write-up — what the human trials measured.
Common Questions
What is the difference between NAD+ and NMN?
NAD+ is the coenzyme itself. NMN is the precursor your body converts into it through the salvage pathway. The published human trials used precursors — NMN in Yoshino and colleagues (Science, 2021), nicotinamide riboside in Elhassan and colleagues (Cell Reports, 2019). Taking the coenzyme and the precursor together is the reasoning behind the Longevity Stack.
When will I notice a difference?
The published precursor trials ran from three weeks (Elhassan and colleagues, Cell Reports, 2019) to ten weeks (Yoshino and colleagues, Science, 2021). That is the kind of window to judge it over, rather than a few days.
Can I take this with other supplements?
Yes. NAD+ and NMN together cover both the coenzyme and the precursor rather than doubling a single dose — that is exactly what the Longevity Stack is. There is no known interaction with the rest of the range.
†These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Servings Per Container 30
This information is provided for educational purposes and is not medical advice. Consult your physician or a qualified healthcare provider before starting any supplement regimen — particularly if you are pregnant or nursing, taking prescription medication, or managing a diagnosed condition.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.